inherited cancer gene

Question

[Leon]

Hello, I wanna design a panel to detect inherited caner(e.g inherited breast cancer) gene variation, but I have no idea about how to find these relatived genes. Any suggestion will be appreciated. Thank you

Answer 1

[prabin.dm]

There are many such panels available and published. Oncotype Dx is one I can think of, and here is some from pubmed.

[Leon]

any web site can provide such genes?

Answer 2

[Kevin Blighe]

Just search online - the genes included in the panel may be listed in the original publications.

Oncotype Dx® and MammaPrint® were developed from gene expression studies, and that is what they measure.

For re-sequencing panels for hereditary cancer, there are many, such as:

• Illumina® TruSight Cancer Sequencing panel (gene list Here (Excel file)
• AmpliSeq™ Inherited Cancer Research Panel for Illumina®

Those are for cancer, generally; for breast cancer, here is one option:

• AmpliSeq™ for Illumina® BRCA Plus, Extended Hereditary Breast and Ovarian Research Panel

You can also look at the panels from my former lab:

• https://www.sheffieldchildrens.nhs.uk/sdgs/next-generation-sequencing/

Others who I know who develop re-sequencing panels have been working in their respective field for many years and know the genes off by heart. It seems that you are not even from a breast cancer background...?