Mutated gene based pathway enrichment

Question

[CY]

My goal is to find dysfunctioned pathways using mutated genes of hundred tumor samples as input.

There are tools like GSEA that take expression data and perform pathway enrichment. I am wondering if there is similar enrichment tools that take mutated genes as input instead and perform enrichment analysis?

Answer 1

[H.Hasani]

You can try geneontology or enrichr if you are not an R user. You can also start with this thread Tutorial: Easy way to do GO enrichment in R and take it from there to explore other R packages.

hth