proteome data analysis

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5.5 years ago

aswanikrishnap1994 ▴ 20

**i have 2 samples A & B proteome data analyzed using progenesis software. i have max fold change reported to be infinity. How will i convert these fold change to log2fc values for heat map generation?

proteomics data analysis • 1.2k views

ADD COMMENT • link 5.5 years ago by aswanikrishnap1994 ▴ 20

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From a mathematical point, log(Inf) = Inf.

ADD REPLY • link 5.5 years ago by Jean-Karim Heriche 27k

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biologically these are significant proteins which are unique to one particular sample

ADD REPLY • link 5.5 years ago by aswanikrishnap1994 ▴ 20

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If you don't want/can't use Inf, you need to come up with a replacement value. For visualization purposes, I guess any value that's higher than the max of the rest of the data could do. What to do really depends on what you want to achieve.

ADD REPLY • link 5.5 years ago by Jean-Karim Heriche 27k

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You posted this as a Forum. I have changed it to a Question.

ADD REPLY • link 5.5 years ago by Kevin Blighe 88k

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