Activator o repressor protein in a pathway

Question

[garcesj]

Hi there,

Maybe it's a very basic question but I've surfed the (almost entire) web without any success... Once you've performed an functional enrichment (either ORA or GSEA) and detected key GOs or pathways implied in your disease, how can you know if a specific gene within a specific GO has a activator or repressor role on it?

I guess it depends of the kind of data you're processing:

• For transcriptomic info a possible solution could be to see if this pathway has a transcription factor and its levels of expression... but what happens if there's no one?
• For genomic data (WES, WGS, etc., this is my case) I'm totally lost... any suggestion??

Thanks in advance!