Diseased tissue gene expression source

Question

[ebrudermanver]

I know that there are many sources such as GTex or Human Protein Atlas that provides information about whether a gene is expressed in a tissue. Is there a similar source which shows how much a gene is expressed in diseased tissues ?

[GenoMax]

cBioPortal would be one source to see this information for cancer.

Answer 1

[Denise CS]

In Open Targets, we use differential expression data from disease vs health tissue comparisons, sourced from Expression Atlas to compute associations between drug targets and diseases. The expression data (in addition to others) is integrated, analysed, scored and displayed as "decreased" or "increased" activity e.g. BRAF in astrocytoma. The original source of data is also provided.

You may want to explore the differential expression experiments from Expression Atlas directly and get the raw differential expression data. There are other resources, such as the RNASeq data available in the The Aging, Dementia and Traumatic Brain Injury Study, cancer samples from TCGA, to name a few.