How to know whether identified mutation signatures from my data are listed in COSMIC site?

Question

[agicict]

I used SomaticSignatures package in R and got some mutation signatures.

I usually designated specific signatures by comparing my signatures and listed signatures in COSMIC site through my eye. https://cancer.sanger.ac.uk/cosmic/signatures_v2

I would like to know whether there are more statistically reasonable method to match the most similar signature to each of my signature.

[Ram]

You should be able to download a VCF (or similar file) from COSMIC and use that to automate your lookup operation.

[agicict]

Thank you for your comment. Do you mean that I should identify mutation signature from the VCF files and then compare it with my data?

[Ram]

What do you mean by signatures? I'm just saying that you should be able to automate what you're doing manually using either downloadable files or querying APIs or a combination of both.

Answer 1

[igor]

There are packages available specifically for that purpose, such as MutationalPatterns or deconstructSigs.

[agicict]

Thank you for your suggestion.