How to find significantly mutually exclusive expressed genes in TCGA

Question

[Mike]

Hi everyone,

I want to check how some of my interesting genes are statistical significantly mutually exclusive expressed in BRCA-TCGA expression data. Does anyone know how to do this?

Thanks

[zizigolu]

Mutually exclusive expressed genes or mutually expressed genes?

[Mike]

I am looking for mutually exclusive expressed genes

[shoujun.gu]

The easiest way is to run Correlation Test for each pair of genes. But there maybe some limitations.

Answer 1

[27atcggcta27]

I'm not sure I understand the question, but have you tried using rMATS? (Detection of splice variants ex. mutually exclusive exons)

[Mike]

rMATS is for detect differential alternative splicing events.