Why kinship is a random effect while population structure is a fixed effect in GWAS studies?
0
0
Entering edit mode
5.2 years ago
rimgubaev ▴ 340

Hello everyone! The mixed linear models frequently applied for GWAS account for confounding factors like fixed (population structure) and random effects (kinship). I am confused with the following thing: The population structure information for example PCs are calculated based on genotype data and kinship matrix is also calculated based on genotype data. So basically both have one source but nevertheless considered as different types of confounding factors. I understand that population structure is definitely a fixed effect by drawing an analogy with herd in animal husbandry or a planting plot in horticulture. However it is still not clear why kinship should be considered as a random effect then.

Kinship matrix Principle components GWAS MLM • 1.8k views
ADD COMMENT
0
Entering edit mode

I have the same question.

ADD REPLY

Login before adding your answer.

Traffic: 1759 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6