Question

How to know does DNA variant sequencing (eg. somatic variant) affect to Protein structure?

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5.1 years ago

9521ljh ▴ 50

i have the result of fusion gene of DNA and also check RNA-sequencing.

Then my question is, how to know these fusion gene really affect to protein?

RNA-Seq rna-seq sequence sequencing next-gen • 739 views

ADD COMMENT • link updated 5.1 years ago by V ▴ 410 • written 5.1 years ago by 9521ljh ▴ 50

score 4 · Accepted Answer · 2019-10-19

I don't think there is a direct way of answering this. You can always check the corresponding amino acid sequence of the fusion gene and compare it to the native protein amino acid structure and make an educated guess. If you've suddenly got a replacement of half the gene, or if you've introduced a novel hydrophobic domain where you had a hydrophilic domain then yes you've probably affected the protein.