Differential expressed genes by mix models

Question

[yusuf]

Hi,

I am confused with the tutorials of Gemma and Macau.

I hope someone has worked with Poisson mix models - MACAU2 and Linear mix model - Gemma to process RNA-seq count data for DE genes. I am confused about why and how to get a relatedness matrix and get DE genes.

I want to compare these two models for my own data.

Kind regards, Yusuf Khan