Question

capture-based plasma cnv calling

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4.7 years ago

lffu_0032 ▴ 90

Hi, Is there any tools can be used to call CNV in capture-based plasma sequencing data? Thanks a lot.

capture-based panel data plasma CNV cnv • 701 views

ADD COMMENT • link updated 4.7 years ago by Kevin Blighe 88k • written 4.7 years ago by lffu_0032 ▴ 90

score 0 · Answer 1 · 2020-03-03

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Entering edit mode

4.7 years ago

Kevin Blighe 88k

You could try DNAcopy (R) or Control-FREEC, or just use a customised method that utilises circular binary segmentation (CBS) and adjusts for sequencing depth across samples / libraries and also GC content.

Kevin

ADD COMMENT • link 4.7 years ago by Kevin Blighe 88k