SeqMan NGen is said to be able to assemble a genome on a desktop computer. It uses a patented algorithm. It provides a fully functional free trial. Has anyone tried it? Does it work that magically?
In my humble opinion; there is no such thing as a magic box with default settings in de novo assembly.
We tried the Ngen as well as one of its direct compettitors CLCbio genomic workbench...which also works from a desktop computer for smaller sized genomes....you still need quite some computational power if you want to do large eukaryotic stuff..... Currently for Illumina data 150bp+ we are quite comfortable with multiple kmer assemblies using ABYSS.
My 2ct.
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