Detecting Biomarkers from Time Series Gene Epression data

Question

[donnieDarko]

Hello,

I have analyzed Time series Gene Expression Data and done following analysis:

1. Found DEG.
2. Performed clustering.

Now I want to find biomarkers from above data, can you suggest me some tools/steps to find/paper to do that? And how to validate those found biomarkers?

Please Help.

[ashish]

See table 1 in this paper. It details many methods for classification of time series expression data.

[donnieDarko]

Sir, I wanted to know about methods/tools to find potential biomarkers from clusters/modules of genes and validate them, I have already performed clustering on the data.

[ashish]

Clustering and classification are diffetent things. If you see the table I suggested, It has a section for classification methods. You can use these methods to find biomarkers. Open the tool links, there are references where people have done what you are trying to do.

[gayachit]

Biomarker for what? Time series experiments usually have some external stimulus or process. It will be difficult to get a biomarker unless you narrow it down. As suggested by @ashish the table has a pretty good summary.