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4.6 years ago
donnieDarko
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0
Hi, I have modules/clusters of gene expression data, and now I want to find/select representative genes from each cluster/module. Can you suggest me of any tool/method to perform selection of representative genes from modules ?
What do you mean by representative genes ?
All genes that belong to a module are the module genes. If you are talking about co-expression modules, you can get genes with top 'n' connectivity or top 'n' genes ranked by their correlation etc but these are all arbitrary depending on what you want to do with "representative" genes.
I have performed clustering on time series gene expression dataset, now I want to perform biomarker discovey as per the step no. 11 to 17 from this image:
from this paper :A clustering-based approach for efficient identification of microRNA combinatorial biomarkers, hope this helps understanding my problem.