What is the best reference genome for Mir-seq analysis

Question

[sabaghianamir70]

Hi

I am currently studying on MiRNAs with analyze the Mir-seq,s data. So I am wondering what is the best reference genome to use for this analyze. Hg19 or 38 and Hg38 Full I know hg38 is newer and better, But the mean part of my question is about hg38 and hg38 full. In MiRNA analysis, which one is better ? is it make any difference anyway ?

Regards

Answer 1

[GenoMax]

my question is about hg38 and hg38 full.

I assume by full you are referring to genome which has alternate haplotypes etc. I don't think haplotypes are going to be important for your miRNA analysis.