Amino acid substitution to nucleotide substitution conversion
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4.6 years ago
Gene_MMP8 ▴ 240

I have a list of oncogenic mutations from the OncoKB database. The data looks someting like this

Gene    Alteration    Oncogenicity
CBL      P417A        likely oncogenic
CBL      N454D        likely neutral

I want to convert the above data set into the following format

Gene    Alteration   Location  Pathogenicity
CBL      P417A       chrX:Y-Z   likely oncogenic
CBL      N454D       chrA:B-C   likely neutral

Where X,A are chromosome numbers and B,C,Y,Z are genomic positions. Is there a straightforward way to do this? I have 1000s of such mutations.

R sequencing • 688 views
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