Hi, guys.
I am using TargetScan Fish, which has not been updated in a while, to find targets for a given miRNA. TargetScan Fish provides the gene IDs for representative 3'UTR target genes. I am using bioMart to find the names of these genes and find orthologous in other species. However, when I input the 5K target genes from TargetScan Fish into bioMart (for current genome version), I get around 900 genes that do not have names as those IDs are retired.
ENSEMBL FAQ: ""A gene ID can change if the gene structure changes dramatically, for example if a gene is split into two, or alternatively, two genes are merged into one.' This makes me wonder if such changes would be as big as making those genes losing their status of predicted targets and if I should remove them from my analysis.
I am aware that I could use BioMart with an older genome version to find their respective names, but I am not convinced whether this would be the best approach biologically speaking.
I would appreciate the thoughts of the community.
Thank in advance.
Gabriel
