It appears that the software that you link to consist of a large number shell scripts that in turn execute various other tools such as bwa, samtools, GATK etc. It also appears to require the Sun Grid engine.
I would guess that it will run just fine on a Mac but it also seems that since it consists of so many small interdependent pieces managing it will require substantial system administrator skills.
I used https://www.virtualbox.org/, you can find your favorite linux image from http://virtualboxes.org/images/ (or by googling around a bit)
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Are you having problems with the installation, or do you want to know how satisfactory someone finds it?
I would like to know whether HugeSeq runs on Mac OS X desktop.
Please correct your link, you have an extra string in the url i.e. "HugeSeq"
Cheers