pathway analysis vs gene enrichment analysis....

Question

[revenge.com]

What's the difference between pathway analysis and gene enrichment analysis? Also what do applications like "DAVID" do for gene enrichment analysis?

[revenge.com]

Hello again...

do applications like DAVID, AMIGO, Reactome, KEGG do the gene set enrichment analysis for you? All you have to do is copy and pasted a ranked gene list?

Answer 1

[Jean-Karim Heriche]

Gene set enrichment analysis, as the name implies, looks for over/underrepresented groups of genes. Typical pathway analysis is performed by setting the groups of genes in gene set enrichment analysis to represent pathways.
What the applications like DAVID do in this respect depends on the statistical approach they take to determine over/underrepresentation and on how they define pathways.