Tumor subclonal architecture using DNA methylation arrays

Question

[ResearchR]

Dear all,

I would like to reconstruct the subclonal make-up of various solid tumor types based on their epigenetic profile using 450k/ 850k methylation arrays. Literature research resulted only in methods using sequencing based methods, such as RRBS (Lee et al., 2019, Barrett et al., 2017; Li et al., 2014). Does anyone have an idea, whether such methods are also available for DNA methylation array data?

Thanks guys!