dbSNP rs number

Question

[kwanghoon]

Hi,

I downloaded annotated-mutation information from TCGA-GBM (mutect2).

I found some dbSNP_RS is NA and novel.

Should I remove these mutations?

[ATpoint]

Absolutely not. Just because something is not in the dbSNP doesn't mean it is not meaningful, in contrast, it can be an interesting variant.