How to understand and analyze allele count from dbNSFP

Question

[Maxime]

Hi,

I have access to multiple VCF files already annotated with SnpEff + dbNSFP and I'm looking at this info field : 1000Gp1_AC so the allele count for phase 1 of 1000G.

I'm analyzing denovo variants and their effect on proteins in disease context.

I have a denovo variant which give me an AC of 410 and is present in 7 probands (2400 analyzed). What can I do with this information? Where can I find the total count of alleles?

I'm guessing it means that this position is very inclined for that mutation and that it shouldn't play a real effect but that's very vague.

Thank you,

Maxime