Is GWAS genotype QC to exclude samples with inbreeding coefficient typically applied to only autosomes?
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4.3 years ago
curious ▴ 820

I am read this QC pipeline:

https://sites.google.com/a/broadinstitute.org/ricopili/preimputation-qc#TOC-Technical-Details

They say to exclude samples with heterogeneity F statistic, also known as the inbreeding coefficient +- .2.

This is probably referring to autosomes only right? I would think this cutoff would not work if including sex chromosomes.

My understanding is that plink --het "computes observed and expected autosomal homozygous genotype counts", so I would guess most people probably just use that, unless they are renaming chrs.

gwas plink • 1.3k views
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autosomes is enough. if you want to use chrX, that's fine

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