Entering edit mode
4.2 years ago
valentinatsar
•
0
Hi all!
One question regarding regional heritability mapping analysis of 50K sheep genotypes using reacta and gcta software.
The sample size is very low and as a result I get errors such as: "the matrix V becomes negative-definite because of one of the variance component is negative" .
The suggested solution is to run the analysis without the --reml-no-constrain option where I get the error: "analysis stopped because more than half of the variance components are constrained. The result would be unreliable"
Any suggestions to perform the analysis successfully even with low number of individuals?
Many thanks in advance! Valentina
