Hello all, I have done proteogenomics study to get a final list of peptide. when peptides were mapped to gene I found that three peptide mapped to a single transcript in three different frame, what does it mean?
at first thought that might be a case of isoforms, in which exons of different frames are used.
it could however also be due to non-specific mapping? do these peptide also map to other regions in the genome/proteome or are they uniquely mapped?
Do the peptides map to the same region of the gene btw? if they map to different regions than that is not really surprising they map in different frames as eukaryote genes have exons that are derived from different frames in the genome.
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