database of ligand->receptor->TF(or transcriptional target)

Question

[mk]

Is there an online database or package-based tool to find interactions where each record has at least:

1. ligand gene
2. receptor gene
3. transcriptional target
4. direction of regulation [is (4) up or down in response to (1,2)]*

* (4) can just be omitted if (3) is always up in a certain database

Any species is fine (I have fish data), since I can just map the orthologs with biomart.