Is it valid to use differential gene expression analysis tool for scRNA-seq with bulk RNA-seq data?

Question

[tofukaj]

Dear all great helpers,

As indicated by the title, I'm wondering if it is valid to use differential gene expression analysis tool for scRNA-seq with bulk RNA-seq data. I curiously tried applying MAST package with the low input RNA-seq data of my interest. It rendered me better results than those acquired from DESeq2 and EdgeR. According to my limited knowledge, I noticed some discussions about applying bulk RNA-seq DE analysis with scRNA-seq but not vice versa.

Best regards, Kaj

[ATpoint]

What does ‚better‘ mean?

[tofukaj]

More significant genes acquired.