how can i evaluate the different between two samples of distribution of peaks in the genome of chip-seq

Question

[zhao03]

Hi i showed the heatmap of TSS region used Deeptools, and found there was a different between two samples, however, how can i get a statistic(p value or fold change?) to indicate the difference? thank you for your help!

[i.sudbery]

As far as I am aware, there is no standard, broadly applicable way to put a p-value on the difference between samples in these sorts of analyses.