RVTests cmc beta coefficient

Question

[Caragh]

Hi there,

I am carrying out rare variant burden analysis on a quantitative trait. I have run this using the cmc method in RVTests, however I need to calculate a beta coefficient for each gene to see the direction of effect. I'm not sure how to go about doing this or even if this can be done for a cmc test.

Also, I have tried running the cmcWald test as this computes the beta coefficient and standard errors, however I'm having trouble interpreting the output. Each gene has 9 different p-values associated with it.Has anyone ran a similar test who would be able to help interpret this?

Any help would be greatly appreciated.

[pampana.akhil]

hey @caragh, i know its a very old message, but have you got solution for this? Please do let me know about this. Thank you Akhil

Answer 1

[evadnie.rampersaud]

Hi,Not sure if you received an answer. Can you tell me how many covariates you have in your model? Each beta and pvalue usually represents the trait and each covariate. Its what you would expect from a logistic or multiple linear regression based analysis.