how to choose hub genes in wgcna

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4.1 years ago

parinv ▴ 80

hello, I am following this tutorial and calculated gene significance(GS) and inter-module connectivity of genes: module membership(MM). I came across some studies (example: 1, 2) where they used GS and MM cutoff to choose hub genes.

can anyone suggest which method to use to select hub genes? and provide an R script for selecting hub genes based on GS and MM cutoff.

Thankyou

Parin

R wgcna • 8.4k views

ADD COMMENT • link 4.1 years ago by parinv ▴ 80

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This paper could help you regarding hub gene identification by R package (dhga) hub gene identification

ADD REPLY • link 4.1 years ago by tothepoint ▴ 940

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Hi Parin

Check out similar posts on Biostars and see if that helps

Hub selection in WGCNA

How to find the hub genes in the gene co-expression network constructed by WGCNA

Similar posts appear on the right of the original post

ADD REPLY • link 4.1 years ago by lakhujanivijay 5.9k

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