Mutual Information for a collection of FASTA files

Question

[nameuser]

Hi there,

I currently have a series of python programs that FASTA files are run through. At the end of the current work flow, the files are given an output displaying the nucleotide distribution. I am mapping the correlation between nucleotide position and gene expression.

Below is a short snippet of the A,T, G, C output

31 , 125066 , 77 , 38 
84 , 59 , 35 , 125032 
74 , 40 , 6 , 125082 
125107 , 44 , 24 , 36 
3 , 44 , 4 , 125161 
125122 , 23 , 28 , 37

I am now attempting to calculate mutual information in python. I have a program using data frames that gets me to the marginal distribution but I am struggling to access the data from multiple files to sum the information for the MI calculation.

If anyone has any suggestions for FASTA --> MI please let me know!