how do we calculate polygenic risk score?

Question

[mag]

Hi,

Can anyone explain, how do we calculate the polygenic risk score? Can anyone give an example?

[JC]

https://lmgtfy.app/?q=polygenic+risk+score+calculation

[lassefolkersen]

I just launched a dockerhub version of the impute-me polygenic risk scoring calculator: https://hub.docker.com/repository/docker/lassefolkersen/impute-me - the advantage is that it has a graphical user-interface, so at least it's easy to use. And the results page tries to explain the process as well as possible

Answer 1

[Kevin Blighe]

There is no standard to how these are calculated. Most seem to be derived from the beta coefficient after having fit a regression model to the data, and may thereafter be 'weighted' by some other value. If a Bayesian regression model is used, then model 'priors' (weights) can be used to weight the coefficients during model fitting.

Kevin

Answer 2

[farshad.madani]

Read this article: https://www.ashg.org/publications-news/trainee-newsletter/201811-polygenic-risk-scores/