From idat Illumina Infinium MethylationEPIC to CNV analysis for homo/hetero-zigous deletion

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4.1 years ago

giammarco.collemi • 0

Hi,

My group works on cancer and we have difficulty on a little part of our last project about malignant pleuric mesothelioma. I'm looking for help in the analysis of .idat from genome-wide DNA methylation profiles obtained via Illumina Infinium MethylationEPIC BeadChips. In particular, I already have CNV plot useful to visualize gene loss or gain, but I am looking for a specif tool to identify automatically homozygous / heterozygous deletions or chromothripsis, with error estimation (related to the quality of DNA sample) and using an adequate threshold of statistical significance.

I would really appreciate your kind help to solve this quest.

ChIP-Seq genome R • 1.0k views

ADD COMMENT • link updated 3.3 years ago by NS • 0 • written 4.1 years ago by giammarco.collemi • 0

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Hii Giammarco,

Hopefully you have searched tool to identify automatically homozygous / heterozygous deletions of CNV Epic methylation data.

I would truly appreciate your support

ADD REPLY • link 3.3 years ago by NS • 0

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