Investigating the dynamic range of a microarray platform from data

Question

[scolobs]

How do I calculate the linear dynamic range of an array platform from a dataset of many samples. Any references to previous published or freely available work will also be appreciated.

NB. I understand what the linear dynamic range should be, but just don't know how it's calculated from generated data from an array.

Answer 1

[Kevin Blighe]

There may only be data held at manufacturers' sites in relation to this. However, I checked, and, sure enough, John Quackenbush has published on this topic: The limits of log-ratios

A useful starting point for you.

It's likely alluded to in his other work, too: Computational analysis of microarray data

Kevin