Mixed Illumina Methylation data from EPIC and 450k

Question

[Pac314]

I am analyzing some mixed methylation array data from EPIC and 450k arrays using Minfi and would like to know whether the two arrays can be combined using combineArray() function prior to initial QC and normalization. Please could you advise me on how to combine the array data without compromising downstream analysis.

[gs000095]

Hey, did you figure out how to do this? :)

I was also thinking about performing QC and normalization and separately and then combining, however, this paper shows how they performed normalization together for both arrays as they had prepared a virtual array.

Looking forward to your reply!