The ERC-funded laboratory of Christof Niehrs studies regulatory DNA and RNA modifications, which play important roles in development & disease. We utilize highly sensitive mass spectrometry (Triple Quadrupole Mass Spec) and stable isotope metabolic labelling to profile epigenetic and epitranscriptomic changes, including 5mC, 5hmC, 5fC, 5caC, m6A, and others.
The Project
The successful candidate will study nucleic acid modifying enzymes to unravel how chemical modifications in DNA, RNA and R-loops regulate pluripotency and differentiation of mammalian embryonic stem cells and embryos.
You will use mass spectrometry, genome-edited CRISPR/Cas9 stem cell mutants, as well as various NGS protocols to carry out a multi- dimensional analysis to address:
Which modifications can be identified and how do they change with different cellular states?
Where in the genome and in which RNAs do the modifications occur?
What are molecular determinants involved in targeting of modifications to specific sites?
The project will involve strong interaction with computational biologists.
For more information, see https://www.imb.de/students-postdocs/imb-postdoc-programme/apply-for-postdoc-positions-at-imb/christof-niehrs
Required Qualifications
PhD & publications in a relevant field Experience in RNA-DNA biochemistry
Excellent communication skills and good team spirit
- Ability to solve problems independently
- Fluent in English (spoken and written)
How to apply
Please see details on the project, information on how to apply, and an online application form at http://www.imb.de/postdocs. IMB is an equal opportunity employer.
The deadline for applications is 28 January 2021. Interviews will take place online. Interview dates will be announced once available.
Application webpage: http://www.imb.de/postdocs
