Entering edit mode
3.8 years ago
english.server
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300
To obtain differentially methylated points when starting from un normalized TCGA methylation beta values hosted at eg Xena browser, is there a need to normalize data before differential analysis? This is what I think is the usual practice as recommended in different BioC methylation analysis pipelines. I do not understand why one should normalize beta values. Are not these values already comparable between different arrays and different in this regard to eg expression values in microarrays?
