hardware for SNV analysis

Question

[rajeefa]

Hi,

I need to do SNV analysis as part of genetic screening program in a clinical setup. The sequencing data(fastq files) will have around 300X coverage from WES . The software for SNV analysis to generate clinical reports works in parallel architecture. My question is that which would be the best architecture to use traditional-processing or HPC server for such an analysis. Initially it would be around 180 samples which would later increase.

It would be really helpful if anyone can give me suggestions on it since this is first time am dealing with the hardware requirements.

[rajeefa]

Thanks for the answer. It was for setting up local cluster.

Answer 1

[GenoMax]

If you need to purchase and set up a local cluster this is likely well beyond advice people can offer on a forum. You will need to work with your existing IT and security policy within the budget you have available.

If using cloud is a possibility then check out this paper.