ERROR with METAL

Question

[d.s.zimmerman]

Good day,

I am busy performing a meta-analysis with my own GWAS results with summary statistics from a paper that has done a similar study to mine with different cohorts. The paper has their MarkerNames as rsIDs while my own summary statistics are in chr:bp:a1:a2 format (eg 10:87086125:A:G ). I converted over the rsIDs to match my own study MarkerNames. However, when I run my METAL analysis I get the following error

###########################################################################
## Running second pass analysis to evaluate heterogeneity...
## Processing file '/home/dominicz/GWAS_SCA/metal/SUDSMETAL_N_with_header'
## ERROR: Input file has changed since analysis started
## WARNING: Heterogeneity analysis failed...

Has anyone run into this issue or know how to fix it?

Thanks!

[Pierre Lindenbaum]

I don't know METAL.

https://github.com/statgen/METAL/blob/master/metal/Main.cpp#L1476 error occurs when the metadata 'header' is different from a 'history' file.

[d.s.zimmerman]

Hi there,

I see, I am not quite sure what a history file is though? I don't see that included in the quick start guide. Thank you for your reply though!

[bjyxszd]

Hi,

I got the same error and came across your pose. Did you find out why?

Thanks!