Linear regression on genotype data

Question

[khatami.mahshid]

Hello all,

I want to find the gene expression value from the genotype data. I have this genotype data for these specific SNPs for some donors:

POSITION           CHR       donor1        donor2        ...       donor100
    100             1          0/0           0/1         ...         1/1
    102             1          0/0           1/1         ...         1/0
    110             1          1/0           1/0         ...         1/1
    ...

I also have gene exoression ( in FPKM ) of these donors for some genes in chromosome 1:

   Gene            donor1        donor2        ...       donor100
   gene1             1.1          14.3         ...         21
   gene2             10.3          7           ...         15
   gene3             14           9.7          ...         21.4
    ...

Do you have any idea that I can do this or not? I think maybe linear regression be a good approach but I'm not sure. I also search for related papers but I didn't find anything. I would be really thankful if help me or send related papers you know.

thanks a lot.

Answer 1

[halo22]

Linear regression is a statistical method used to model the relationship between two variables. You can predict the value of one variable based on the other. Your post is not very clear. I believe you are trying to extract gene expression data based upon the genotypes that you have. A gene is not just a single position (as genotype) but a multiple-base-pair composition.

[khatami.mahshid]

yes but linear regression has something name multiple linear regression which makes a relationship between one variable and multiple variables