Is mutation activating or inactivating?

Question

[aredd1990]

Hello,

I have next gene sequencing data available. It provides me with mutational information. I have used http://mutationassessor.org/r3/ to interpret the mutation which provides FI score and Functional Impact (ie. high, low, neutral).

Is there a way to determine if the mutation is an activating mutation or inactivation mutation?

Thanks

[GenoMax]

You may want to try Ensembl Variant Effect Predictor (LINK).

Answer 1

[halo22]

Try looking into ANNOVAR and VEP.