Human Genome Homology With Other Species [Genetic Similarity]

Question

[Sukhi Singh]

Ola!

Is there a interactive web application/page which keeps track of what is the homology or Genetic similarity of human/mouse genome with other species plus flora including the variability factors like sex, origin, variations in the genome, evolution etc. I could find this information spread over lot of different resources but not in one place.

[Josh Herr]

Are you talking about homology across all organisms? I would think there is such phylogenetic breadth that this type of viewer would be problematic? Something like USCS genome browser for all organisms with metadata?

[Sukhi Singh]

Yeah, If not visually may be just in numbers, a genome browser with a window for all organisms with all metadata will be quite advanced and sophisticated.

[Josh Herr]

Although it's a tough computational nut to crack, it sounds like where we are going with data integration and I can't wait to see it all happen.

[Sukhi Singh]

Sure and I have a feeling either its done to some extent or some one is already doing it :)

Answer 1

[Alex Paciorkowski]

I'm not sure if you need to compare entire genomes at once, or only regions of interest.

VISTA contains a couple of tools multiple DNA sequence alignment data that may be helpful to you that allow cross-species comparisons:

mVISTA and also Phylo-VISTA

[Sukhi Singh]

Alex, I don't want to compare them myself but would like to see if some resource is up to date and contains information about these comparisons.