Example Of Residue Mutation And Related Disease

Question

[Reyhaneh]

Hi;

I am looking for a few examples where it has been proved that a mutation of an interface residues in a protein-protein complex has inhibited the binding of the 2 proteins and resulted in a crucial disease.

Do you have any suggestions?

Thanks in advance

Answer 1

[cmyates89]

Here are a few papers which you may find useful:

http://www.ncbi.nlm.nih.gov/pubmed/22072597

http://www.ncbi.nlm.nih.gov/pubmed/22252508

http://www.ncbi.nlm.nih.gov/pubmed/19888216

[Reyhaneh]

Thanks for these