What Problems (If Any) Should I Expect When Combining Identifiers Based On Different Releases Of Dbsnp?

Question

[Brian Tsai]

hi, i'm pulling dbsnp ids (rsid) from two different datasets that use different versions of dbsnp (132 versus 137), both of which include SNP chromosome coordinates. i was wondering what dangers lie in mixing rsids from different versions together? thanks

[Sudeep]

Have you seen How To Map Snp Profile From Dbsnp Build 131 To 132? post ?

[zx8754]

Use LiftOver before "mixing rsids". Web interface: http://genome.ucsc.edu/cgi-bin/hgLiftOver Command line: http://hgdownload.cse.ucsc.edu/admin/exe/linux.x86_64/liftOver

[aindap]

If the versions of dbsnp use the same assembly I'm not quite sure how LiftOver helps.

Answer 1

[Istvan Albert]

The most immediate problems would arise from different genomic builds if that is the case as Sudeep commented see: How to map SNP profile from dbSNP build 131 to 132?