Number Of Chromosomes
2
0
Entering edit mode
11.7 years ago
James ▴ 80

Hi guys,

How is the number of chromosomes determined from a newly sequenced bacteria genome. Can this be verified from the sequence data?

Thanks
James

biology sequencing sequence • 2.7k views
ADD COMMENT
8
Entering edit mode
11.7 years ago
JC 13k

Bacteria (generally) has only one circular chromosome (but can contain multiple plasmids), therefore your sequencing must show only one large contig.

ADD COMMENT
5
Entering edit mode

I guess this may be true for many bacteria, but as with many things in biology there are always exceptions. There are bacteria with linear chromosomes and multiple chromosomes (as well as collections of plasmids). See e.g. http://microbewiki.kenyon.edu/index.php/Chromosomes_in_Bacteria:_Are_they_all_single_and_circular%3F#Multiple_Chromosomes and http://micro.cornell.edu/cals/micro/research/labs/angert-lab/genomes.cfm.

To the original question: I think it would be unusual to assess chromosome count from sequence alone. The typical way would be genetic experiments (see papers in the references above) or maybe FISH or PFGE. This isn't my area so I might be very wrong.

In principle, with very high coverage sequencing and long reads, you could assemble the sequencing reads and the number of contigs would equal the number of chromosomes. In practice, of course, repetitive sequence and other problems would break up the chromosomes and you'd have many more contigs than chromosomes.

ADD REPLY
0
Entering edit mode

I agree, biology always comes with exceptions.

ADD REPLY
1
Entering edit mode
11.7 years ago

The short answer is no. Even a very very good de novo assembly will have more contigs than chromosomes.

ADD COMMENT

Login before adding your answer.

Traffic: 1373 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6