Identification Of Protein Complexes In A List Of Proteins

Question

[Pappu]

I have a set of 2500 uniprot IDs. Now I want to identify if the proteins in my list are actually forming a complex. I found out CURUM database of complexes: http://mips.helmholtz-muenchen.de/genre/proj/corum I am wondering if there is any tool to figure out which complexes are present in my list of proteins (something like DAVID enrichment analysis).

[Michi]

Did you find any solution? I am confronting the same problem

[Mo]

@Michi Did you find any solution? If so, it would be nice to know it.

Answer 1

[Fidel]

Besides CORUM the PDB is also a good source for complexes.

Answer 2

[Khader Shameer]

+1 CORUM; If you are interested in curated subset of complexes from human proteome - you can also consult HGNC gene families list. There is a total of 17 curated complex with a total of 263 genes.

Actin related protein 2/3 complex subunits
Anaphase promoting complex subunits
Biogenesis of lysosomal organelles complex-1 subunits
Components of oligomeric golgi complex
Elongator acetyltransferase complex subunits
General transcription factor IIH complex subunits
HAUS augmin-like complex subunits
Histocompatibility complex
INO80 complex subunits
Mitochondrial respiratory chain complex assembly factors
Mitochondrial respiratory chain complex / Complex I
Mitochondrial respiratory chain complex / Complex II
Mitochondrial respiratory chain complex / Complex III
Mitochondrial respiratory chain complex / Complex IV
Mitochondrial respiratory chain complex / Complex V
THO complex subunits
Trafficking protein particle complex

Answer 3

[Giovanni M Dall'Olio]

Protein Complexes are also annotated in Reactome. I don't think there is a tool to do what you want, but you can download the mapping files and parse them to get the proteins associated to any complex.