Direction And Sign Of Interaction In Protein-Protein Interactions

Question

[pegahtv]

Hi, I am interested to know if there is any database containing the direction and sign of interaction in protein-protein interactions.

Thanks.

[Pierre Lindenbaum]

can you please describe what are "direction" (location?) and "sign"(regulation?) ?

[pegahtv]

by direction I mean if P1 interacts with P2 or vice versa.

[pollyD]

I suppose, most databases are capable of doing so. For example, turning on the 'actions view' in the STRING database (http://string-db.org) provides such information if it's available, e.g. http://string-db.org/newstring_cgi/show_network_section.pl?taskId=Woo70GUVtvhc&interactive=yes&network_flavor=actions

[pegahtv]

thanks a lot. It is exactly what I was looking for.

[Neilfws]

To clarify these comments. It rather depends how you define "interaction".

If protein A is known to act upon protein B in some regulatory manner, then that interaction could be said to have a direction and a sign. However, where interaction simply means "is physically associated with", as in many PPI databases, then that is modelled as an undirected graph.

Answer 1

[enunvillafer]

Reactome database