Transcription Factor And Corresponding Target Gene Resources

Question

[Woa]

Hello I'm looking for transcription factor resource that would give a list of transcription factors and their corresponding target gene(s).

The species I'm mostly interested in are Mouse and Rat.

I've found this database but there can be a better resource.

http://itfp.biosino.org/itfp/TFViewer/mouse_tf.jsp?table=mouse_tf&page=1

Thanks

Answer 1

[Charles Warden]

In general, there are databases like TRANSFAC and JASPAR for transcription factor binding motifs, and various tools that utilize the matrices present in those databases.

I think this interface provides the functionaity that you are looking for:

http://rulai.cshl.edu/cgi-bin/TRED/tred.cgi?process=searchTFGeneForm

More commonly, I tend to work with lists of differentially expressed genes, and I am looking for what motifs are enriched in a given gene list. GATHER is one good, open-source tool for doing this (although there certainly are others):

http://gather.genome.duke.edu/

If you are interested in de novo prediction of enriched motifs, I would recommend SCOPE:

http://genie.dartmouth.edu/scope/