Mirna Or Tf Enrichment, Onlinedatabase? Webserver? Local Database?

Question

[J.F.Jiang]

Hi all,

I get a set of co-expressed genes, since co-expressed genes are mainly due to regulation via elements such as miRNA, TFs... So I want to take a look which miRNA and TF are significantly enriched for these genes?

The tool I know is WebGestaly, Is there anyother onlinedatabase avalaible?

Thanks

Answer 1

[Sasha Fokin]

hello, J.F.Jiang

We are now building a similar database and online dataviz tool -- MirOB (MicroRNA OncoBase).

Database includes validated microRNAs and Transcription Factors Targets associated with human cancers. More 6500 interactions with special emphasize on the specific types of cancer, pathological processes and expression level alterations. Currently, MirOB supports only homo sapiens organism.

You can try the early demo-version here: http://mirob.interactome.ru/pathway_navigator

We have a lot of experimenting and often change the various functions. According to this, we regularly see errors that we fix on the fly.

Please help us to find these errors.

[J.F.Jiang]

OK, good resources for enrichment analysis. Will introduce it to my colleagues.