What Are The Most Influential Cadd Papers Of 2011?

Question

[dimkal]

Inspired by this post about the most influential scientific article in bioinformatics of 2011, I'd like to ask what's the most ground-breaking/influential recent article in the field of CADD (Computer-Aided Drug Discovery/Design).

To make it fun, lets also add the most ridiculous article (à la _Ig Nobel_.)

[Egon Willighagen]

Have you tried running altmetrics on the CADD journals to see what ends up high in the rankings?

[dimkal]

looks like it's a paid service. correct me if i'm wrong.

[Egon Willighagen]

Some is, indeed. Sorry, I should have checked that :(

Answer 1

[Woa]

This paper is about structural biology but could have a far reaching consequence so far CADD is concerned

Crystal structure of a monomeric retroviral protease solved by protein folding game players

http://www.nature.com/nsmb/journal/v18/n10/full/nsmb.2119.html

[dimkal]

There's a great interview with David Baker, the author of the article and of FoldIt game, on Futures in Biotech podcast (#92).

http://twit.tv/show/futures-in-biotech/92

[Woa]

Thanks for the link

Answer 2

[Flow]

This is one methodological advancement that I really like;

http://pubs.acs.org/doi/abs/10.1021/ja202726y